My husband is 48 with metastatic prostate cancer this has become resistant to hormal treatments and he has weakened what else can be given?

Different options: There are many options available nowadays for metastatic prostate cancer besides the good old androgen blocker medication. Among of them include- chemotherapy - like taxotere, jevtana-other oral meds- like zytiga (abiraterone acetate) (abiraterone), xtandi, Provenge vaccine- all optional and available for your husband. Some other therapies including radioimmunotherapy /nuclear medicine are also in the pipeline.

Zytiga (abiraterone acetate): Talk to your husbands doctor about the suitability of ytiga and ketoconazole therapy.

Many options: Taxotere (docetaxel) is usually next step but now 3 or 4 choices of things to treat, and some can give great responses with minimal toxicity. He is very young for this disease; any breast cancer or ovarian cancer in his family? He should test for the brca gene mutation ( www.Myriad.Com ).

Many options: This is an exciting time for hormone refractory prostate cancer. There is fda approved vaccine (dendreon), chemotherapy, many potential clinical trials. He is young and seems to have aggressive disease. Bone health is very important for him to prevent skeletal related events. Have him evaluated at an advanced prostate cancer center that has options to treat on clinical trials.