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A member asked:
What is peripheral destruction/ sequestration of neutrophils? ps: i already know what are neutrophils.
5 doctors weighed in across 2 answers
Multiple things: Neutrophils may be destroyed in circulation due to auto-antibodies, may be "sequestered" in an enlarged spleen, or be consumed in an overwhelming infection.
Answered 3/13/2013
5.2k views
Autoimmune Dz: Certain autoimmune diseases can form antibodies against neutrophils triggering destruction of these white cells in the peripheral circulation. Splenomegaly due to liver disease & portal hypertension can cause sequestration not only of neutrophils but other blood cells in the blood as well leading to entrapment of white and red blood cells & platelets in the spleen causing pancytopenia.
Answered 8/12/2016
5.2k views
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