Really dry skin on big toe knuckle? how can i get rid of this?

Hand cream: Most dry skin problems respond to simple moisturizing. The trick is to apply consistently until the skin softens. Also be careful not wear irritating shoes. If the problem doesn't resolve, see a podiatrist who can prescribe a stronger skin softening agent like urea cream.

Try CeraVe lotion: This lotion provides a great moisture barrier for dry skin. You should see the difference in a few days.