Can second hand smoke come out in your drug screen?

Yes, but at much : Lower levels than in the urine of active smokers. Besides nicotine and its metabolites, there are other markers of tobacco use like anabasine, present in tobacco products, but not in nicotine replacement therapies & nornicotine, in tobacco products & as a metabolite of nicotine. So, if you smoke while on nicotine replacement, claiming it was passive smoking won't fly. Sorry.