What is the definition or description of: cryoglobulinemia?

Abnormal proteins: In cryoglobulinemia blood contains large amounts of cryoglobulins - these abnormal proteins are insoluble at low temperatures. These are present in lot of autoimmune conditions as well as other conditions.

Insoluble proteins: Cryoglobulinemia is a condition in which a person's blood contains a large amount of a specific type of protein called cryoglobulins. This type of protein can clump up (become insoluble in blood) at reduced temperatures. These insoluble proteins can then block small blood vessels and cause clinical symptoms. Patients with multiple myeloma or hepatitis c can develop cryoglobulinemia.