CLL IgVH: Immunoglobulin variable region (igvh) mutation status is an important marker for prognosis in patients with cll. Testing is by polymerase chain reaction (pcr) amplification of the igvh region, followed by dna sequencing. Ref: http://www.Mayomedicallaboratories.Com/articles/hottopics/transcripts/2008/2008-11b-cli-pt-2/11b-26.Html.
Answered 12/2/2012
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A test 2 assess risk: The correct name is igvh mutational status assay. This is a gene test performed only on leukemic cells of patients with cll to assess risk of progression, and death from cll. The readout is either mutated (which is favorable) or unmutated (unfavorable). Igvh mutations happen during the normal generation of antibodies in white cells.
Answered 6/6/2014
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