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A 28-year-old male asked:

what is the definition or description of: chronic lymphocytic leukemia ivgh?

2 doctor answers4 doctors weighed in
Dr. Michael Thompson
Hematology and Oncology 20 years experience
CLL IgVH: Immunoglobulin variable region (igvh) mutation status is an important marker for prognosis in patients with cll. Testing is by polymerase chain reaction (pcr) amplification of the igvh region, followed by dna sequencing. Ref: http://www.Mayomedicallaboratories.Com/articles/hottopics/transcripts/2008/2008-11b-cli-pt-2/11b-26.Html.
Dr. Julio Hajdenberg
Hematology and Oncology 31 years experience
A test 2 assess risk: The correct name is igvh mutational status assay. This is a gene test performed only on leukemic cells of patients with cll to assess risk of progression, and death from cll. The readout is either mutated (which is favorable) or unmutated (unfavorable). Igvh mutations happen during the normal generation of antibodies in white cells.

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A 21-year-old member asked:

What is acute lymphoblastic leukemia (all)?

4 doctor answers11 doctors weighed in
Dr. Stephen Noga
Medical Oncology 34 years experience
Lymph system cancer: Lymphocytes are normal cells of the immune system that protects the body from infection. When these cells become cancerous, they grow out of control in the bone marrow, blood and other organs. All is very common in children but can occur in adults. With children, it is truly one of our success stories thanks to clinical trials with cure rates above 90%. Adults do not do as well.
A 33-year-old member asked:

Can you have leukemia and not anemia?

2 doctor answers7 doctors weighed in
Dr. Michael Thompson
Hematology and Oncology 20 years experience
Yes: Advanced leukemia of any sort (aml, all, cml, cll) can lead to anemia. However, early leukemia (rai 0 cll) may not result in anemia.
A 53-year-old member asked:

I want to know what is the difference between anemia and leukemia?

2 doctor answers7 doctors weighed in
Dr. Michael Thompson
Hematology and Oncology 20 years experience
Different cells: Emia = blood. An-emia = lack of red blood cells (low hgb) associated with fatigue leukocytosis = more white blood cells (WBC) in the blood. One cause of leukocytosis is an increase in WBC cancer cell called leukemia.
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A 42-year-old member asked:

Is it possible for someone to have leukemia and not anemia?

2 doctor answers6 doctors weighed in
Dr. Stephen Noga
Medical Oncology 34 years experience
Yes: Depending on the type of leukemia, this is possible. For example, chronic lymphocytic leukemia is a slowly prgressive disease and it may take a while before the marrow becomes significantly involved to the point of affecting the red blood cells. Also, in the early stages of leukemia, anemia may not be present.
A 48-year-old member asked:

Could the disease leukopenia lead to leukemia?

2 doctor answers5 doctors weighed in
Dr. Stephen Noga
Medical Oncology 34 years experience
Possibly: There are a lot of reasons for leukopenia. Usually isolated low white cells is not a sign of leukemia if the red blood cells and the platelets also found in blood are fine. Leukopenia develops in leukemia because all the bone marrow cells that eventually end up in the blood stream are crowded out by leukemia cells.

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Last updated Jun 6, 2014

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