What is the significance of ischemia?

See below: Ischemia implies insufficient blood flow. Myocardial (heart) ischemia is usually due to plaque obstructing blood flow. It can also be due to coronary artery spasm (especially in smokers). Ischemia often causes chest pains but can be painless (silent ischemia). Medical therapy is preferred to control risk factors. Invasive therapy such as angioplasty or bypass surgery is for unstable patients.

Poor perfusion: Ischemia is caused by low or inadequate blood flow and oxygen delivery to a tissue: heart attack stroke amputation renal failure are sequellae of ischemia.