How does coronary artery disease disrupt homeostasis?

Can weaken the heart: If the blockage results in a heart attack, the heart muscle can get damaged and not contract as hard. That would definitely disrupt homeostasis.

Blocks blood flow: Homeostasis is a process whereby the body's systems are kept balanced in good working order. In the heart chemical signals from heart muscle that is not getting enough oxygen will cause blood vessels to dilate and increase the blood flow to those tissues. Coronary artery disease can prevent this increase in blood flow by creating blockages in the coronary arteries.