A member asked:

Can i get mono twice mono?

10 doctors weighed in across 3 answers

Once : Once a patient has had mono, they will always test positive for the virus. In general, patients only get true mono one time, but if the patient is very "run-down", or susceptible from physical stressors, the virus can re-activate and cause mono symptoms and can also be contagious again.

Answered 10/3/2016

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No, but....: The classical mono is caused by EB virus, and you only get it once. Afterwards you will have lifelong immunity. However, there are other germs that can cause a mono like illness. Acquisition of this 2nd or 3rd germs could give you a similar illness.

Answered 2/8/2017

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Most get it once: Most people get mono only once. Rarely mono can recur or reactivate. Also bear in mind there are other viral infections that have the same symptoms as mono. More about mono: http://www.mayoclinic.org/diseases-conditions/mononucleosis/expert-answers/mononucleosis/faq-20058564

Answered 3/13/2019

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