A 37-year-old member asked:
Disclaimer

what is the difference between the stage and the grade of lung cancer?

3 doctor answers
Dr. Mitchell Kamrava
15 years experience Radiation Oncology
Refer to diff things: Stage refers to the extent of the disease. It includes the size of the tumor (t stage), whether lymph nodes are involved (n stage), and whether it has spread to other sites of the body (m stage). The TNM stages are put together to give an overall stage of i-iv. Grade refers to what the tumor cells look like under the microscope and are usually graded as low, intermediate, and high.
Answered on Feb 13, 2015
1
1 comment
2
2 thanks
Dr. Reza Shirazi
19 years experience Radiation Oncology
Grade: how aggressive the cells are behaving when examined under the microscope. Staging as Mitch described helps us in predicting prognosis and designing appropriate treatment
Nov 10, 2011
Dr. Ritesh Rathore
29 years experience Hematology and Oncology
A lot: Stage refers to extent of cancer: generally stage 1 & 2 are early cancers; stage 3 involves spread to the nodes or structures in the middle of the chest; stage 4 involves spread to both lungs or other organs. Grade refers to the degree of abnormal appearance of the cancer when seen under the microscope- usually grades range from 1-3.
Answered on Jul 20, 2012
1
1 comment
Dr. Michael Thompson
19 years experience Hematology and Oncology
I agree. Further, you can have a high grade (micro), low stage cancer (eg breast cancer) as well as a low grade, high stage cancer (eg, indolent lymphoma). Both grade and stage are important prognostic factors, but very different features of the cancer.
Dec 22, 2011
Dr. David Cooke
21 years experience Thoracic Surgery
Difference: Stage refers to the size and invasiveness of a tumor (t) involvement of lymph nodes (n) and evidence of metastasis (m). Grade refers how organized or differentiated a tumor is as it looks underneath a microscope.
Answered on Nov 1, 2013
3
3 thanks

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Get help now:

Ask doctors free
Personalized answers
Free
Talk to a doctor
Unlimited visits
$10/month

Related questions:

A 30-year-old member asked:
Dr. Creighton Wright
55 years experience General Surgery
Several: Pneumonia copd emphysema other infections pneumothorax are all lung disease. Cancer is malignant growth of some cell type squamous adeno smal ... Read More
1
1 thank
A 37-year-old member asked:
Dr. Carlo Hatem
24 years experience Pulmonary Critical Care
Clinical behavior: Small cell grows rapidly, and seems more susceptible to chemotherapy and radiation. Non-small cell actually refers to a number of different types that ... Read More
4
4 thanks
A 32-year-old member asked:
Dr. Rada Ivanov
30 years experience Pulmonary Critical Care
Entirely different: Different types of cancer. Small cell multiplies fast and is considered spread at the time of diagnosis. Because of that, it may also respond better t ... Read More
1
1 comment
1
1 thank
A 24-year-old male asked:
Dr. Michael Fiocco
34 years experience Thoracic Surgery
3b is more advanced: Although both stages are serious, stage 3b tends to have more severe lymph node spread, usually meaning spread out side the affected side of the chest ... Read More
3
3 thanks

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Get help now:

Ask doctors free
Personalized answers
Free
Talk to a doctor
Unlimited visits
$10/month