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A 34-year-old member asked:

Does transposition of the great vessels happen because of genetics?

2 doctor answers8 doctors weighed in
Dr. Barton Cook
Pediatric Cardiology 32 years experience
No: Transposition is one of the only congenital heart defects that has no increased risk of recurrence in families.
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Dr. Richard Roberts
Pediatrics 47 years experience
Yes and no: There are many genetic syndromes in which a cardiac malformation occurs, including transposition. However, there are other causes as well, such as the fetal effects of maternal diabetes, exposure to substances which can cause birth defects, and reduced folic acid in pregnancy. There are unknown patterns of malformations which we do not understand--heart defects with renal, ear, and vertebral.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Richard Roberts
Pediatrics 47 years experience
Provided original answer
Prospecdtive study of 100 IDDM babies-1% had D-TGA. d-TGA cases,-pf 369 sibs, 1 had a heart defect (0.27%). 50 sibs of l-TGA-1 sib with a heart defect (2%). Heart defects in 2 of 143 (1.4%). Sibs of a complex TGA, and 1 of 50 (2%) sibs of asplenia with TCA. Many genes are now known, 1 causing impaired intellect. Deletion at 22q11.2. Genetic analysis and counseling for recurrence risk indicated
Jun 26, 2015

Similar questions

A 38-year-old member asked:

What are the tests for transposition of the great vessels?

1 doctor answer1 doctor weighed in
Dr. Mario Matos-Cruz
Thoracic Surgery 40 years experience
ECHO,CATH.,MRI: Echocardiogram diagnostic, emergency cardiac cath for rashking procedure if needed, and to determine coronary anatomy, if a concomitant vsd present, intracavitary pressures and shunt may possibly be determined. Cardiac MRI may be needed for concomitant vascular anomalies and assistance in situs inversus.
Created for people with ongoing healthcare needs but benefits everyone.

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Last updated Oct 4, 2017
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