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A 34-year-old member asked:

Does transposition of the great vessels happen because of genetics?

2 doctor answers8 doctors weighed in
Dr. Barton Cook
Pediatric Cardiology 31 years experience
No: Transposition is one of the only congenital heart defects that has no increased risk of recurrence in families.
Dr. Richard Roberts
Pediatrics 46 years experience
Yes and no: There are many genetic syndromes in which a cardiac malformation occurs, including transposition. However, there are other causes as well, such as the fetal effects of maternal diabetes, exposure to substances which can cause birth defects, and reduced folic acid in pregnancy. There are unknown patterns of malformations which we do not understand--heart defects with renal, ear, and vertebral.
Dr. Richard Roberts
Pediatrics 46 years experience
Provided original answer
Prospecdtive study of 100 IDDM babies-1% had D-TGA. d-TGA cases,-pf 369 sibs, 1 had a heart defect (0.27%). 50 sibs of l-TGA-1 sib with a heart defect (2%). Heart defects in 2 of 143 (1.4%). Sibs of a complex TGA, and 1 of 50 (2%) sibs of asplenia with TCA. Many genes are now known, 1 causing impaired intellect. Deletion at 22q11.2. Genetic analysis and counseling for recurrence risk indicated
Jun 26, 2015

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A 38-year-old member asked:

What are the tests for transposition of the great vessels?

1 doctor answer1 doctor weighed in
Dr. Mario Matos-Cruz
Thoracic Surgery 39 years experience
ECHO,CATH.,MRI: Echocardiogram diagnostic, emergency cardiac cath for rashking procedure if needed, and to determine coronary anatomy, if a concomitant vsd present, intracavitary pressures and shunt may possibly be determined. Cardiac MRI may be needed for concomitant vascular anomalies and assistance in situs inversus.
A 35-year-old member asked:

How do they fix transposition of the great vessels?

2 doctor answers2 doctors weighed in
Dr. Mario Matos-Cruz
Thoracic Surgery 39 years experience
Arterial vs atrial: When anatomy ideal, hypothermic cardiopulmonary bypass and cardioplegic arrest done, aorta transected, left main and right main coronary buttons made, pulmonary artery transected, lecompte maneuver done, coronary buttons translocated to neoaorta, aorta is anastomosed to left v-a trunk, pulnomary artery anastomosed to reconstructed pulmonary trunk.Atrial switch operation may be required otherwise.Asdcl.

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Last updated Oct 4, 2017
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