A member asked:

What is the difference between actonel (risedronate) and fosamax?

2 doctors weighed in across 3 answers

Chemical structure: Actonel (risedronate) and Fosamax are drugs in the bisphosphonate family. They have similar but not identical structures. They produce similar benefits for osteoporosis patients.

Answered 6/25/2014

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Dr. Arthur Heller answered

Specializes in Gastroenterology

Similar, but differ: Both are bisphosphonate drugs, taken orally, which decrease bone breakdown by osteoclast cells, and therefore increase bone density (a marker of bone strength). Different dosing, but can be weekly or monthly for either in osteoporosis. Were used in tumors to or to bone-now drugs mostly given IV for that. Fosamax (alendronate) stays in the system and bone longer; was thought to be more GI irritating (maybe not).

Answered 9/20/2018

5.8k views

Thank
Dr. Arthur Heller answered

Specializes in Gastroenterology

Similar, but differ: Both are bisphosphonate drugs, taken orally, which decrease bone breakdown by osteoclast cells, and therefore increase bone density (a marker of bone strength). Different dosing, but can be weekly or monthly for either in osteoporosis. Were used in tumors to or to bone-now drugs mostly given IV for that. Fosamax (alendronate) stays in the system and bone longer; was thought to be more GI irritating (maybe not).

Answered 12/18/2018

5.8k views

Thank

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