What is the best over-the-counter drug to prevent premature ejaculation?

No: There isn't a good over the counter drug. There is a topical numbing agent applied to the penis sold under various names. There are also no fda approved drugs for pe yet. All prescriptions are off label at this point. Working with a sex therapist can help couples learn various effective techniques to delay ejaculation.

Sexual dysfunction: Many people who have premature ejaculation or erectile dysfunction are embarassed or afraid to receive help. The first thing to do is to talk to your family doctor to see if there is a medical problem that needs to be addressed. Taking an over the counter drug might cover up a problem that needs professional attention with a doctor. There is help available, and you are not alone by any means.