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A member asked:
Why there is different bioavailbilty of different dosage form of digoxin?
A doctor has provided 1 answer
Bioavailability: Oral drug usually pass through the liver after absorption from the GI tract. This removes a certain amount (first-pass). Injectable forms bypass this . Oral liquids have a better abosrption profile than tablets and so may peak higher. In the long run it the steady state levels over a long period that are important.
Answered 6/10/2014
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