A member asked:

What is the link between the alpha-1 antitrypsin deficiency and the emphysema ?

3 doctors weighed in across 2 answers

Good and Bad: Alpha one is a disease where a good enzyme is missing in the bloodstream. Normally this enzyme prevents bad enzymes from destroying lung tissue. If the level of the good enzyme is low then lung tissue is destroyed resulting in emphysema. There are both mild and severe forms of Alpha one.

Answered 6/24/2014

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Dr. Hesham Hassaballa answered

Specializes in Pulmonary Critical Care

Destruction: Alpha-1 anti-trypsin is a protective chemical in the body that prevents destruction of lung and other tissues from the damage that the infection fighting cells can inflict. When you have a lack of this chemical, the destruction of the infection fighting cells in the body can go unopposed. This is especially true when someone smokes, which attracts those cells to fight off the toxins in the smoke.

Answered 11/10/2012

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