What would cause balls of feet and palms of hands to itch and cause upper flank pain?

Allergic reaction: Palmar and plantar itching (palms and soles) usually signifies an allergic reaction, but flank pain generally means a kidney problem like an infection or stone. It's unusual to have both together. Either one could signal a serious problem, though, so it's important to see a doctor and get all this sorted out soon.

I do: Not believe the flank pain is related to the itching. The itching can be from fungus, allergy, diabetes etc. Discuss this with your family dr.