Should a 16 year old girl who has gender disorder be treated with prozac (fluoxetine) and testostorne ?

Transman?: Testosterone is for contrahormal therapy (masculinization). Prozac (fluoxetine) is for depression, anxiety or ocd. The two drugs are compatible and treating both (all) conditions is necessary in a transperson. Be sure to have a competent experienced person treating your gender dysphoria and other problems. Also counseling with a therapist experienced in transgender is a must.

Seek expert guidance: Depression, distress &anxiety are very common among transgender-identified kids & teens. Tragically, more than 25% of trans-identified teens commit suicide. It's a cause of great suffering when your internal experience of yourself doesn't match your external appearance, voice, etc. For someone who identifies as male but was assigned "female" at birth, testosterone can be positively life-changing.