What could high estrogen, and low testosterone mean for a male?

Wrong ratio: Too much estrogen & not enough testosterone in a guy could lead to hypogonadism which characterized by fatigue, loss of energy, cloudy thinking, depression, loss of sex drive (libido), erectile depression, inability to gain muscle in response to exercise, inability to lose fat in response to proper nutrition, male breasts, etc. Low t is also linked to diabetes, obesity, heart disease, stroke, etc.