Can progesterone defiency cause placental abruption ?

Great question!: Not known. Placenta is the major producer of Progesterone in pregnancy, and Progesterone serves to keep the uterus quiet as the fetus grows. It is possible that perturbations in the uteroplacental interface (eg placental infarction) could lead to both Progesterone decline and increased risk for abruption. No study has addressed this to date; abruption remains an impossible complication to predict.