Does wellbutrin (bupropion) affect libido?

Indirectly: Depression can depress libido, and wellbutrin is an antidepressant. Treating depression can improve all symptoms that come with it, including loss of libido. If wellbutrin is the medication used, then some say it improved libido. Wellbutrin can also help revive libido that is suppressed by ssri antidepressants like zoloft, celexa, and paxil (paroxetine). Its mechanism of action differs from these others.

Yes And No: Many antidepressant medications can cause a loss of libido. Some estimate as many as 35% of patients may experience this side effect. Wellbutrin (generic bupropion) is an exception and rarely causes a loss of libido. Since depression itself can cause a loss of libido and by treating the depression with wellbutrin, one may actually improve their libido with wellbutrin.