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A 33-year-old member asked:

Is reperfusion injury?

2 doctor answers7 doctors weighed in
Dr. Vasu Brown
Integrative Medicine 35 years experience
Reperfusion injury: Reperfusion injury refers to tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. The absence of oxygen and nutrients from blood during the ischemic period creates a condition in which the restoration of circulation results in leaking from blood vessel the substances that produce damage to tissue - the degraded enzymes create further damage.
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Dr. Joseph Sucher
Trauma Surgery 27 years experience
Great Question!: Reperfusion injury is something that occurs when an organ or extremity is denied blood flow (perfusion) and subsequently blood flow is restored. At this point, without very specific therapy and monitoring, reperfusion injury can ensue. The cytotoxins are released at this point, with resultant cellular injury and apoptosis occurring. This can lead to limb or organ damage/loss.
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Similar questions

CA
A 38-year-old member asked:

How can a reperfusion injury be lethal?

2 doctor answers4 doctors weighed in
Dr. Tracy Berg
General Surgery 33 years experience
Organ failure: Reperfusion injuries are rare, complex. Loss of blood flow comes with swelling and increased pressure in limb. The leg's fascial compartments can not expand. When blood flow is restored and compartments released, reperfusion occurs. The metabolic waste products previously trapped, now get out of the leg. These waste products can overwhelm the other organs, shutting them down.
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Last updated Jan 15, 2015

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