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A 22-year-old member asked:

How can you inherit down syndrome?

3 doctor answers6 doctors weighed in
Dr. Robert Kwok
Pediatrics 33 years experience
Yes: A woman with Down syndrome (trisomy 21) may be able to get pregnant, but men with Down syndrome are almost always sterile, due to problems with sperm production. That means about half of the babies born to women with Down syndrome will inherit an extra chromosome #21 and be Down syndrome babies. Said another way, if you inherited down syndrome, your mother must have had down syndrome.
Dr. James Ferguson
Pediatrics 46 years experience
Depends on parents: An unaffected mother or father could have a balanced(normal) set of chromasome material where a piece of one 21 chromasome is stuck on another.If the egg or sperm had the normal 21 and an extra 21piece hidden on another chromasome, they could pass it to the baby. It only takes an extra piece of 21 to cause ds.It is important to study ds to verify type, as translocation ds can recur each pregnany.
Dr. William Singer
Pediatric Neurology 51 years experience
Occurs at fertilizat: Down syndrome is a chromosome disorder in which an infant inherits 3 number 21 chromosomes. This occurs at fertilization. the extra chromosome is usually thought to be from the mother, but there are circumstances where it can be contributed by father. In rare cases, a portion of a 21 chromosome becomes attached to another chromosome, causing Down syndrome.

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A 31-year-old male asked:

What is down syndrome?

1 doctor answer3 doctors weighed in
Dr. James Ferguson
Pediatrics 46 years experience
Chromosome defect: Ds is one of the more common chromosome(c) defects that can survive pregnancy (many others miscarry).Eggs are supposed to have a single 21c & combine with the 21 from dads normal sperm.Here a pair of moms 21c +dad's 21 creates a baby with the extra 21c in all tissues.This extra material confuses the creation of body parts causing ds..Various prenatal tests can pick up signs early on.

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Last updated Nov 8, 2016

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