Is it safe to take anti-histamine tablets with wine?

Increase of effect: One or two drinks probably won't be much of an issue, because alcohol becomes a sedative/depressant after a couple of drinks. Antihistamines can be sedating and mixing the two likely will increase the effect of sedation which can impair your judgement/ability to operate machinery etc...If u do so in evening and staying home, should be safer! be good. Just don't drink and drive. Good luck.