What is the best way to treat septicemia?

Fluids, antibiotics: In general sepsis is best treated in a monitored setting with aggressive IV fluid resuscitation, appropriate antibiotics, isolation and potentially removal of the source of infection, and if needed, ventilator support, pressor medication support and blood transfusions.

Identify source: First of identify the source of infection and direct antibiotics to the cause. If an abscess is present it needs to be drained. Other supportive measures may be required such as IV fluids, medications to support blood pressure and o2.