Slightly: Because cholesterol synthesis is maximal around midnight if your sleep pattern is normal, and maximal onset of action with Simvastatin is a few hours after taking it, there is a few percentage points benefit for taking it in the evening. Long acting statins (atorvastatin & rosuvastatin) are less impacted by time of day.
Answered 10/4/2016
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When to take statin: Best time to take statins which is a medication for cholesterol is one hour before dinner.
Answered 5/8/2013
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