How long will it take for peridex (chlorhexidine gluconate) to work?

1 week to 3 months: It depends on the severity of your periodontal disease, frequency of professional therapy, & compliance with home care instructions. It also is influenced by your overhealth status.

Starts Immediately: Since Peridex (chlorhexidine gluconate) is applied directly to where the problem is, it starts working right away. What varies, however, it how well it will work long-term, and how much it will improve your condition. That, in turn, depends on what your condition is and what you're expecting Peridex (chlorhexidine gluconate) to do. For the most common oral problems, you should notice an improvement within 2 weeks. Don't use it long-term.