A member asked:

How can prion can cause cns damage? is the prion encoded into our dna permanently?

A doctor has provided 1 answer

Unknown and yes: We all have the prion protein in our dna. Its normal function is unknown. Problems occur when something causes this protein to misfold. Misfolded prion protein may induce normally folded prion proteins to also misfold. It is unknown how many misfolded prion proteins are needed to cause disease. Recent research suggests misfolded prions may shut down protein synthesis. Nature 2012, 1476-4687.

Answered 8/20/2018

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