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A 35-year-old member asked:

Can you explain mosaic turner syndrome?

2 doctor answers2 doctors weighed in
Dr. David Galbraith
Pediatrics 48 years experience
A little complex: Classic turner syndrome is a female who is missing 1 of the 2 x chromosomes, designated as 46x. A normal female has 2 x chromosomes (46xx). Most turner mosaics have a mix of normal cells and turner cells resulting in a milder form of turner syndrome. There are several variations however-- some with 1 normal and one abnormal x chromosomes and evan a male form with a normal x and an abnormal y.
Dr. James Ferguson
Pediatrics 46 years experience
Timing of error: At conception , the embryo begin duplicating the chromosomes (chms) donated by egg & sperm to form the 23 chromosome pairs. If one x chm didn't make it , you will only have a turner pattern (45 chms xo) . If a normal xx pattern starts but an x is lost after several divisions the mosaic is created by having one normal 46xx & another 45xo cell lines replicating throughput the body.

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A 35-year-old member asked:

Possible mosaic turner syndrome. Please explain it?

1 doctor answer2 doctors weighed in
Dr. Vered Lewy-Weiss
A Verified Doctoranswered
A US doctor answeredLearn more
Variation of Theme: Most females have 2 x chromosomes as part of their genetic make-up in all cells. In classic ts females are born with 1 x chromosome in most or all cells. Patients who are mosaic are those who may be missing just part of an x or they could have some cells with 2 x's and others with only 1 x. There are other variations. Mosaic ts patients are usually not as severely affected as classic ts patients.
A 29-year-old member asked:

What is mosaic turner syndrome? Common symptoms?

2 doctor answers2 doctors weighed in
Dr. James Ferguson
Pediatrics 46 years experience
Two cell lines: Regular turner syndrome arises when the drop out of one "x" sex chromosome occurs before or at conception, then all babies cells would have xo turner. When it drops out after conception, after the first, second or whatever cell division, a line of xo affects that cell line but normal xx are in the other cells. Mosaics have less turner specific abnormalities but effect varies on % of affected cells.

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Last updated Sep 6, 2012

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