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A 47-year-old member asked:

Is adrenal insufficiency hereditary?

2 doctor answers6 doctors weighed in
Dr. Susan Wingo
Endocrinology 33 years experience
It can be.: One cause of adrenal insufficiency, addison's disease, is an auto-immune disorder. The immune system mistakenly makes antibodies targeting one or more proteins in the adrenal cortex, and winds up destroying the adrenal cortex, so that the adrenals can no longer make cortisol, or other hormones. As is true for most auto-immune disorders, a tendency to develop addison's can run in families.
Dr. Gregg Nishi
Bariatrics 22 years experience
Adrenal insufficienc: Most are not hereditary but there is one cause that is thought to be. Type 2 or schmidt's syndrome is a polyendocrine deficiency syndrome.

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A 39-year-old member asked:

Is it true that adrenal insufficiency is hereditary?

1 doctor answer2 doctors weighed in
Dr. Thomas Knecht
A Verified Doctoranswered
A US doctor answeredLearn more
No: Hi. No, not as in a single gene defect. Adrenal enzyme deficiencies (one gene, 2 copies for each enzyme - 1 from mom & 1 from dad) are hereditary. Adrenal insufficiency is usually autoimmune, infectious, malignant, or hemorrhagic; not single gene defects.
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A 33-year-old member asked:

What is adrenal insufficiency?

2 doctor answers8 doctors weighed in
Dr. Susan Wingo
Endocrinology 33 years experience
Low adrenal function: The adrenal glands make a number of different hormones, most importantly cortisol. When a person's adrenals cannot make normal amounts of cortisol, they are diagnosed with adrenal insufficiency, or failure. This can be due to a problem in the adrenals (infection, tumor, bleeding, auto-immune destruction) or in the pituitary or parts of the brain that control the adrenals.

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Last updated Feb 20, 2019

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