Do specific hla antigens predispose someone to ischemic heart disease?

Yes and no: There is no direct correlation between hla types and the incidence of CAD that I am aware of. However, certain hla types, ie b27, are associated with CAD thought due to chronic inflammation and vascular injury. For instance many chronic autoimmune disease patients have a higher incidence of cad.

Yes: The heart and the joints are both of major importance as targets for the hla-b57-associated disease process. Hla-b57-related cardiac lesions may be found in the absence of other rheumatologic manifestations. Similarly there is an association with some hla dr alleles and heart disease.