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A 34-year-old member asked:

Do specific hla antigens predispose someone to ischemic heart disease?

2 doctor answers2 doctors weighed in
Dr. Samuel Hahn
Cardiology 30 years experience
Yes and no: There is no direct correlation between hla types and the incidence of CAD that I am aware of. However, certain hla types, ie b27, are associated with CAD thought due to chronic inflammation and vascular injury. For instance many chronic autoimmune disease patients have a higher incidence of cad.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Gurmukh Singh
Pathology 51 years experience
Yes: The heart and the joints are both of major importance as targets for the hla-b57-associated disease process. Hla-b57-related cardiac lesions may be found in the absence of other rheumatologic manifestations. Similarly there is an association with some hla dr alleles and heart disease.
Created for people with ongoing healthcare needs but benefits everyone.

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Last updated Jun 10, 2014
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