Does dbs surgery allows at least a 50% reduction in sinemet (carbidopa and levodopa)?

Sometimes: Sinemet (carbidopa and levodopa) should be tapered slowly over many weeks to months foll. The combination of DBS and meds usually works better than either alone. There may be some sinemet (carbidopa and levodopa) reduction with a single DBS, and even more with a second DBS. The target allowing the most med reduction is STN. Every patient needs a different approach and everyone is different so it is hard to say how much it can be reduced.