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A member asked:
What is fatal familial insomnia? what causes it?
A doctor has provided 1 answer
FFI is a very rare : genetic neurodegenerative disorder caused by a mutant prion protein gene on Chromosome 20p13. Each child of a parent with FFI has a 50% chance of inheriting it. Mis-folded prion protein "spreads" in the thalamus, the brain area that controls sleep-wake cycles, progressively damaging neurons there. www.cureffi.org/2012/12/03/introduction-to-fatal-familial-insomnia/ explains symptoms & prognosis.
Answered 12/20/2014
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