What is the treatment for trimethoprim overdose?

Drink a plenty fluid: The treatment for a Bactrim (sulfamethoxazole and trimethoprim) overdose will vary. If the overdose was recent, a healthcare provider may certain medicines or place a tube into the stomach to "pump the stomach." treatment also involves supportive care, which consists of treating the symptoms that occur as a result of the overdose. For example, supportive treatment options may include:plenty of fluids by mouth, if possible.