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Midlothian, TX
A 16-year-old female asked:

Can you take benadryl (diphenhydramine) and nyquil at the same time?

1 doctor answer1 doctor weighed in
Dr. Larry Xanthopoulos
Pediatrics 23 years experience
Not best idea: Nyquil has an antihistamine in it already, and benadryl (diphenhydramine) is an antihistamine so you run the risk of overdosing on the antihistamine component. This may cause drowsiness, dryness and can possibly effect respiratory drive. So, not a good idea to take both together.
Created for people with ongoing healthcare needs but benefits everyone.

Similar questions

A 19-year-old female asked:

Can i take Benadryl (diphenhydramine) and nyquil together?

1 doctor answer2 doctors weighed in
Dr. Paul Grin
Pain Management 37 years experience
You can, but: Not recommended due to drug interactions. Both drugs increase sedation and drowsiness.
Created for people with ongoing healthcare needs but benefits everyone.
A 32-year-old member asked:

Can you take Benadryl (diphenhydramine) and hydrocodine at the same time?

1 doctor answer3 doctors weighed in
Dr. Mitchell Cohen
Psychiatry 38 years experience
Be careful: Benadryl (diphenhydramine) can be used with hydrocodone to decrease itching and nausea that sometimes happens with hydrocodone. Benadryl (diphenhydramine) and hydorocodone, however, are both sedating and together cause additive drowsiness. Also both drugs independently can cause constipation and urinary hesitancy, so taken together these problems also can be worse. Be careful and discuss with your doctor.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Jan 29, 2020
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