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Midlothian, TX
A 16-year-old female asked:

Can you take benadryl (diphenhydramine) and nyquil at the same time?

1 doctor answer1 doctor weighed in
Dr. Larry Xanthopoulos
Pediatrics 22 years experience
Not best idea: Nyquil has an antihistamine in it already, and benadryl (diphenhydramine) is an antihistamine so you run the risk of overdosing on the antihistamine component. This may cause drowsiness, dryness and can possibly effect respiratory drive. So, not a good idea to take both together.

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Similar questions

A 19-year-old female asked:

Can i take Benadryl (diphenhydramine) and nyquil together?

1 doctor answer2 doctors weighed in
Dr. Paul Grin
Pain Management 36 years experience
You can, but: Not recommended due to drug interactions. Both drugs increase sedation and drowsiness.
A 32-year-old member asked:

Can you take Benadryl (diphenhydramine) and hydrocodine at the same time?

1 doctor answer3 doctors weighed in
Dr. Mitchell Cohen
Psychiatry 37 years experience
Be careful: Benadryl (diphenhydramine) can be used with hydrocodone to decrease itching and nausea that sometimes happens with hydrocodone. Benadryl (diphenhydramine) and hydorocodone, however, are both sedating and together cause additive drowsiness. Also both drugs independently can cause constipation and urinary hesitancy, so taken together these problems also can be worse. Be careful and discuss with your doctor.

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Last updated Jan 29, 2020
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