Is better to take probiotics with food or at empty stomach?

Experiment with both: Apart from certain probiotics such as saccharomyces boulardii, in clinical testing, most probiotics are inconsistent in their effectiveness in restoring normal intestinal flora functioning. Though pre-meal dosing may work in some people, a post-mealtime dose may work on others. In most cases, it doesn't harm the patient- but is it worth the extra health resource dollars? That'is debatable.