I am 41 and my cycle has been crazy for over a year now. from 27-45 days. last period was 7 weeks ago. negative pregnancy test. what's up?

Might be...: You are already at that period of the female's life where menopause is possible, however, the final determinant would be absence of periods for a year. Follow up with your doctor or GYN provider in order to get labs as it is estimated needed especially due to prolonged periods for that long.

Ovulation issue: As women enter their forties they often times have irregular ovulation, which can lead to skipped periods, irregular periods or very heavy periods. A low dose birth control can help. Also if you're done having children, an endometrial ablation can eliminate them altogether without altering your hormonal status.