A member asked:

I use tretinoin cream to treat p&p. is there any tretinoin resistance if using it for longterm ? if so, can i still use it to stimulate skin turnover?

3 doctors weighed in across 2 answers
Dr. Howard Shapiro answered

Specializes in Internal Medicine - Nephrology & Dialysis

Some cautions below: You should avoid bright sun (use a sunscreen) and avoid multivitamins (which may increase the skin irritation by the drug). I can't find any reports of the medicine losing its effect over time. If irritation occurs, reduce the amount that you use.

Answered 8/28/2014

3.8k views

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Dr. Susan Rhoads answered

Specializes in Family Medicine

P&P?: I am not sure what you mean by P&P. But triretinoin is great medicine and does not cause resistance. Some skin programs do recommend increasing the dosage for a week or two every 2-3 months but this varies. Ask your doctor for his opinion.

Answered 8/28/2014

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