Need MD evaluation: Prednisone can cause fluid retention, but not lymphedema. Lymphedema is due to obstruction of the lymphatic channels in the legs and is a hard, "brawny" edema. The fluid retention from prednisone usually "pits" when you press your thumb into the swelling. You have a complicate medical history; edema needs to be evaluated by your physician.
Answered 8/12/2014
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