Can a severe skin dryness in some places indicate some sort of genetic condition?

Possibly: Dear abosabry8, severe dryness or rough skin in a specific area of the body can be a sign of rare genetic skin diseases. However, these diseases are rare, and most people simply have dry skin. You should try to moisturize the affected area well, and you can try to apply over-the-counter Lactic Acid to remove scales. You can always seek the advice of your local dermatologists.