Do any herbal supplements have dangerous side effects if taken with glipizide and metphormin?

Most : Supplements are safe. But can cause issues if not taken correctly. I don't believe your medications have any majors risks with supplements. But talk to your doctor to be sure. I am not sure what supplements you are taking

It depends: Please see the label. All the mechanism of herbal medications are not known but some of them are notorious to cause side effects due to interaction.