Can you cancel out your depo-provera shot in any way possible?

Maybe: You can't take away the medication in the depot shot once it's been given. Some women, however, have break through bleeding on the shot and those women can benefit from taking birth control on top of the shot. But, no, there's no way to remove the progesterone in the depot shot once it's been given. Only to counter some of its effects with estrogen in birth control pill.