What happens if a person had c. difficile diarrhea after 7 days of ceftin, (cefuroxime) is it safe to give 1gm of ancef iv during surgery?

Sometimes: There is a small but definite risk of C. Diff infection with Ancef (cefazolin) given prior to surgery. In someone who has had a previous C. Diff infection, I would be careful to weigh the risk and benefit of giving a preop antibiotic to prevent the rare surgical wound infection. This should be discussed with your surgeon because the need for Ancef (cefazolin) prior to surgery is also based upon the type of operation.