A member asked:

What is the safest amount of diphenhydramine you can take at once?

A doctor has provided 1 answer

Risks and benefits: Although there are rare times when a doctor may advise you to take as much as 100mg of this drug, it is a better idea not to exceed 25mg per dose. Over 25mg the added risks generally outweigh the benefits.

Answered 7/29/2014

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