What is biological therapy in treating colon-rectal cancer?

Monoclonals: You are probably referring to monoclonal antibodies. These are complex molecules that have been engineered to interact with a specific phase in the cancer cell's biologic pathway. In other words, cancer cells frequently have mutations that are not present in normal cells. If we can block that pathway, then the cancer cell stops growing and dies. Expensive but fewer side effects.

TARGETED THERAPY: These newer targeted therapies include monoclonal antibodies directed at specific receptors or ligands or tirosine kinase inhibitors that interrupt signaling pathways. Ei: bevacizumab, cetuximab, panitumimab, Aflibercept and regorafenib. Of note these agents are used in the metadtatic setting, in other words stage 4. Talk to your oncologist he can guide you better.