A member asked:

How does high density lipoprotein leads to diabetes?

8 doctors weighed in across 3 answers
Dr. David Geffner answered

Specializes in Endocrinology

It does not: Hdl-cholesterol is good. People without sugar problems given statins for high total and ldl-cholesterol have a slight increased risk of developing diabetes. The increased risk however is offset by the decrease in heart attacks with these agents.

Answered 12/24/2012

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Dr. Milton Alvis, jr answered

Specializes in Preventive Medicine

Concur, Backwards: Diabetes, a condition in which people do not keep their blood glucose stable & low normal, but let it rise, is usually associated with low concentrations of high density lipoproteins, especially the largest, most protective HDL particles. If the HDL particles stay small flat disks, the way they form, they are not picking up fat from cells which have too much intracellular fat & not protective.

Answered 6/10/2014

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Dr. Michael Shapiro answered

Specializes in Cardiology

It does not: Low hdl-cholesterol does not cause diabetes. However, diabetes is often associated with low hdl-cholesterol and other abnormalities of lipids and lipoproteins. The derangements of lipids and lipoproteins commonly seen with diabetes is one of the major drivers of increased cardiovascular disease.

Answered 12/17/2014

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