If both parents have thalassemia trait, what will happen with their offspring?

25-50-25: Generally, the hemoglobinopathies are inherited in an autosomal recessive fashion, which means you must have an abnormal copy of the gene from each of your parents. If each parent has one abnormal copy of the same gene, then each child has a 25% chance of being normal, a 50% chance of having one copy of the abnormal gene (trait), and a 25% chance of having two abnormal copies (thalassemia.).