Do isotretinoin reduces the size of sabecious glands permanently?

Not necessarily: Not necessarily. Furthermore, roche pharmaceuticals stopped manufacturing Accutane (aka isotretinoin) in 2009. The official reason was that roche's patent had run out. A number of generic equals are still available. However, many who have used the drug have reported harmful side effects (depression, bowel disease), and the drug is a known teratogen (can cause harm to the fetus) in pregnant women.