Can you die from diphenhydramine overdose?

Unfortunately Yes: The medical literature is filled with cases of deaths related to overdose using diphenhydramine. Normally this over-the-counter agent is very safe when used as prescribed to treat allergic reactions, cold and flu like symptoms, insomnia, and motion sickness. Considerable overdosage can lead to cardiac arrest, serious ventricular dysrhythmias, coma, and death.

Intentional ?: Overdose can occur accidentally or intentionally. Although death by Benadryl (diphenhydramine) overdose is rare, there is an antidote that can be administrated at the hospital to treat the symptoms of overdose. If there is suspicion of an intentional overdose one should always go to the hospital. If an individual refuses to go, immediately call 911. Medical professionals will provide the appropriate care.