What exactly causes restless leg syndrome?

Still unknown fully: It has something to do with iron and Dopamine metabolism but the links are not clear yet.Given the similar circadian rhythms of serum iron levels, the proteins involved in Dopamine transmission, and RLS symptoms, it is difficult not to hypothesize a connection. In fact, iron is a cofactor for tyrosine hydroxylase, which is the rate-limiting enzyme for Dopamine synthesis. www.medscape.com.

Dopamine lack: I think restless leg syndrome is probably caused in susceptible people (tends to be familial) by a relative lack of sufficient Dopamine and is often associated with fatigue, dopamine-blocking medicines, chronic illness, and the end of gestation. Medications that increase Dopamine are frequently helpful as can be Neurontin (gabapentin) and Klonopin (clonazepam)..