Does gallbladder disease have a genetic component?

Yes.: Gallbladder disorders tends to cluster in families. That being said, there is no gene that you can test for to see if you will develop gallbladder disease. For example, one of the risk factors for developing gallstones is being overweight; being overweight tends to run in families.

Yes: Classically this was demonstrated in the pima indian population, but it is common to have a familial trend in non-native americans as well.